Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHJ0EB)

Drug Name

A186 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Clotting disorder	3B4Z	IND submitted	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Coagulation factor XI (F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asundexian	DMLZMU2	Ischemic stroke	8B11.5Z	Phase 3	[2]
Abelacimab	DM09YTN	Atrial fibrillation	BC81.3	Phase 2	[3]
MK-2060	DM79A32	Thrombosis	DB61-GB90	Phase 2	[4]
EP-7041	DMV0MHI	Thrombosis	DB61-GB90	Phase 1	[5]
AB023	DMBG9HI	End-stage renal disease	GB61.5	Phase 1	[6]
A336	DMVQG8G	Clotting disorder	3B4Z	Phase 1	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of Klus Pharma
2	Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa. J Thromb Haemost. 2022 Jun;20(6):1400-1411.
3	Pharmacokinetics and pharmacodynamics of Abelacimab (MAA868), a novel dual inhibitor of Factor XI and Factor XIa. J Thromb Haemost. 2022 Feb;20(2):307-315.
4	Clinical pipeline report, company report or official report of MSD
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809.