Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHTBDN)

• Drug Name: Isojaspic acid Drug Info
• Synonyms: isojaspic acid; CHEMBL1164369

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 46907602
  TTD Drug ID: DMHTBDN

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[3]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[3]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[3]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[3]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[3]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[3]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[3]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[4]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[1]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[4]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[6]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol	DMLDQWT	Discovery agent	N.A.	Investigative	[6]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol	DMO34LJ	Discovery agent	N.A.	Investigative	[7]
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[4]
Jaspic acid	DMOF0TB	Discovery agent	N.A.	Investigative	[6]
DYSIDENIN	DMIZQTX	Discovery agent	N.A.	Investigative	[4]
Polybrominated diphenyl ether derivative	DMG7K84	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[8]
ZD-2138	DMVFCX7	Asthma	CA23	Discontinued in Phase 2	[9]
BW A4C	DMNUMDG	Arthritis	FA20	Terminated	[10]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[11]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[11]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[11]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[1]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[1]
5,3'-Dipropyl-biphenyl-2,4'-diol	DMJRXLD	Discovery agent	N.A.	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 12-lipoxygenase (12-LOX)	TT12ABZ	LOX12_HUMAN	Inhibitor	[1]
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

References

• [1] Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
• [2] Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
• [3] 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
• [4] Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
• [5] Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
• [6] Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
• [7] Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
• [8] New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
• [9] Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
• [10] Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
• [11] Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.