General Information of Drug (ID: DMIAOU6)

Drug Name
SLN124 Drug Info
Indication
Disease Entry ICD 11 Status REF
Beta thalassemia 3A50.2 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMIAOU6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IONIS-TMPRSS6-LRx DM7VJE1 Beta thalassemia 3A50.2 Phase 2 [3]
Sapablursen DM95T5Z Polycythemia vera 2A20.4 Phase 2 [4]
ALN-TMP DMW7XEU Beta thalassemia 3A50.2 Preclinical [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TMPRSS6 messenger RNA (TMPRSS6 mRNA) TTNIUKC TMPS6_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT04718844) A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome. U.S. National Institutes of Health.
2 SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019 Oct 1;3(6):e301.
3 Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
4 Clinical pipeline report, company report or official report of Ionis
5 Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.