Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIEJ0W)

Drug Name

Radiolabelled-huA33 Drug Info

Synonyms

Radiolabelled-huA33 (colorectal cancer); Radiolabelled-huA33 (colorectal cancer), Ludwig; 124I-huA33; 125I-huA33

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Cell surface A33 antigen (GPA33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MGD007	DMAHWLR	Colorectal cancer	2B91.Z	Phase 1/2	[3]
KRN-330	DMA5B1S	Colorectal cancer	2B91.Z	Phase 1/2	[4]
HuA33	DMB3LQU	Colorectal cancer	2B91.Z	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT00291486) Capecitabine and 131I-huA33 in Patients With Metastatic Colorectal Cancer. U.S. National Institutes of Health.
2	(124)I-huA33 antibody PET of colorectal cancer. J Nucl Med. 2011 Aug;52(8):1173-80.
3	Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.
4	Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer. Invest New Drugs. 2014 Aug;32(4):682-90.