Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIKHN0)

• Drug Name: Meticillin Drug Info
• Synonyms: Dimocillin; MII; Metacillin; Methicillin; Methicillinum; Methycillin; Meticilina; Meticillina; Meticilline; Meticillinum; Staphcillin; Methicillin [BAN]; Meticillin [INN]; Meticillina [DCIT]; BRL 1241; Methicillin Monohydrate, Monosodium Salt; Meticilina [INN-Spanish]; Meticilline [INN-French]; Meticillinum [INN-Latin]; Penicillin, Dimethoxyphenyl; (2,6-Dimethoxyphenyl)penicillin; (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2,6-dimethoxyphenyl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2,3-Dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 6-(2,6-Dimethoxybenzamido)penicillanic acid; 6beta-(2,6-dimethoxybenzamido)-2,2-dimethylpenam-3alpha-carboxylic acid; 6beta-(2,6-dimethoxybenzamido)penicillanic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Staphylococcal pneumonia		Approved	[3]
Neurological disorder	6B60	Investigative	[4]
Sinusitis	CA0A.Z	Investigative	[5]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6087
  ChEBI ID: CHEBI:6827
  CAS Number: CAS 61-32-5
  TTD Drug ID: DMIKHN0

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[7]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[8]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[9]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[10]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[11]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[9]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[12]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[14]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Binder	[6]

References

• [1] Post-COVID-19 Infection With Meticillin-Sensitive Staphylococcus aureus (MSSA) Bacteremia, Discitis/Osteomyelitis, and Diffuse Abscesses: A Case Report. Cureus. 2022 Jun 10;14(6):e25824.
• [2] Drug information of Meticillin, 2008. eduDrugs.
• [3] [Staphylococcal pneumonia]. Probl Tuberk Bolezn Legk. 2004;(6):11-7.
• [4] Alpha-conotoxins. Int J Biochem Cell Biol. 2000 Oct;32(10):1017-28.
• [5] Diagnosis, management and treatment of orbital and periorbital cellulitis in children. Emerg Nurse. 2016 Apr;24(1):30-5; quiz 37.
• [6] A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus. Microbiology. 2006 Sep;152(Pt 9):2549-58.
• [7] Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
• [8] Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9.
• [9] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [10] Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7.
• [11] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [12] Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32.
• [13] Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
• [14] Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21.
• [15] Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.