Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIU0VP)

Drug Name

SNX-5422 Drug Info

Synonyms

908115-27-5; PF-04929113; SNX-5422; SNX 5422; SNX5422; UNII-BF52J69Q8T; PF 04929113; PF-04929113 (SNX-5422); BF52J69Q8T; PF04929113; PF-4929113; cc-40; MLS006011083; SCHEMBL1220791; SCHEMBL1220790; CHEMBL1195136; SCHEMBL15604989; DTXSID50238270; C25H30F3N5O4; MolPort-023-293-502; BCPP000065; HMS3656B09; EX-A2343; BCP02427; s2656; ZINC95616595; ABP000737; ZINC100071931; ZINC252517142; AKOS027276395; SB16643; DB06070; API0008143; RL05706; SNX-5422 /; CS-0272; NCGC00346640-01; NCGC00386184-02; Glycine, trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrah

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1/2	[1]
Non-small-cell lung cancer	2C25.Y	Phase 1/2	[1]
Chronic lymphocytic leukaemia	2A82.0	Phase 1	[1]
Neuroendocrine cancer	2B72.1	Phase 1	[1]

Cross-matching ID

PubChem CID: 44195571
CAS Number: CAS 908115-27-5
TTD Drug ID: DMIU0VP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cromoglicate	DM74LZK	Asthma	CA23	Approved	[4]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[4]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[5]
BIIB-021	DMPAJ41	Breast cancer	2C60-2C65	Phase 2	[6]
KW-2478	DMJGL72	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
VER 50589	DMFLZPC	Breast cancer	2C60-2C65	Phase 2	[5]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[8]
Efungumab	DMBHP56	Breast cancer	2C60-2C65	Phase 2	[9]
PU3	DMJO0BP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
Debio 0932	DMWP3G1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Heat shock protein 90 beta (HSP90B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PU-H71	DMIYHAW	Breast cancer	2C60-2C65	Phase 1	[1]
TAS-116	DMRX530	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 90 alpha (HSP90A)	TT78R5H	HS90A_HUMAN	Inhibitor	[2] , [3]
Heat shock protein 90 beta (HSP90B)	TTH5YN2	HS90B_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55.
3	Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr Opin Pharmacol. 2008 Aug;8(4):370-4.
4	Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.
5	Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.
6	BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9.
7	Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68.
8	Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8.
9	Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23.
10	Clinical pipeline report, company report or official report of Debiopharm (2011).