Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIVUFL)

Drug Name

ACH-1625 Drug Info

Synonyms

SOVAPREVIR; 1001667-23-7; UNII-2ND9V3MN6O; ACH-0141625; 2ND9V3MN6O; Sovaprevir [USAN:INN]; Sovaprevir (USAN); Prodrug of ACH-1095; SCHEMBL1462843; CHEMBL2105750; DTXSID00142994; DB12069; SB16836; D10166; 2-Pyrrolidinecarboxamide, N-((1R,2S)-1-(((cyclopropylsulfonyl)amino)carbonyl)-2- ethenylcyclopropyl)-1-((2S)-3,3-dimethyl-1-oxo-2-(2-oxo-2-(1-piperidinyl)ethyl)butyl)-4-

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 2	[1]

Cross-matching ID

PubChem CID: 53362096
CAS Number: CAS 1001667-23-7
TTD Drug ID: DMIVUFL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[2]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[3]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[4]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[5]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[6]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[7]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[8]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[9]
BI 201335	DM3MXT8	Hepatitis C virus infection	1E51.1	Phase 3	[10]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of Achillion (2011).
2	PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
3	Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
4	Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
5	Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
6	Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
7	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9	Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
10	2011 Pipeline of Boehringer Ingelheim Pharma.
11	2011 Pipeline of Bristol-Myers Squibb.