Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIX7CP)

Drug Name

IP-1200 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Erectile dysfunction	HA01.1	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Prostaglandin receptor (PTGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bimatoprost	DMX0E5B	Alopecia	ED70	Approved	[2]
Unoprostone	DMXNR04	Glaucoma/ocular hypertension	9C61	Approved	[3]
Iclaprim	DM7YNV9	Bacterial infection	1A00-1C4Z	Phase 3	[4]
JB991	DMKU6MW	Skin infection	1F28-1G0Z	Phase 2	[5]
Taprostene	DMA4WY5	Thrombosis	DB61-GB90	Discontinued in Phase 3	[6]
ZD-4953	DM5UCHW	Pain	MG30-MG3Z	Discontinued in Phase 2	[7]
TEI-6122	DM3F5E0	Diabetic complication	5A2Y	Discontinued in Phase 2	[8]
YP-009	DMPXLG2	Solid tumour/cancer	2A00-2F9Z	Terminated	[9]
YP-008	DM2N76V	Psoriasis vulgaris	EA90	Terminated	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin receptor (PTGR)	TT9B4N3	NOUNIPROTAC	Modulator	[1]

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References

1	Clinical pipeline report, company report or official report of Immunologic.
2	Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors. Curr Eye Res. 2009 Mar;34(3):184-95.
3	Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1499-504.
4	Novel ocular antihypertensive compounds in clinical trials. Clin Ophthalmol. 2011; 5: 667-677.
5	US patent application no. 2006,0041,016, Composition and method for the treatment of psoriasis.
6	Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807.
7	WO patent application no. 2013,1675,82, Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease.
8	The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells.. Br J Pharmacol. 1995 October; 116(4): 2298-2302.
9	YP 009 York Pharma pc preclinical, UK(cancer), R & D Focus Drug News, November 12, 2007
10	CA patent application no. 841416, Method of selecting therapeutic indications.