Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ4SBM)

Drug Name
N-acetylserotonin Drug Info
Synonyms
N-Acetyl-5-hydroxytryptamine; 1210-83-9; N-ACETYL SEROTONIN; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide; acetylserotonin; Normelatonin; O-Demethylmelatonin; 5-Hydroxy-N-acetyltryptamine; UNII-P4TO3C82WV; Acetyl-5-hydroxy-tryptamine; 5-Hydroxymelatonin; N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide; 3-(2-Acetamidoethyl)-5-hydroxyindole; P4TO3C82WV; CHEMBL33103; CHEBI:17697; MVAWJSIDNICKHF-UHFFFAOYSA-N; Acetamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-; A-1300; Desmethylmelatonin; N-acetyl-serotonin; O-demethylmelatonin; N-acetyl-5-hydroxytryptamine; N-[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-acetamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
903
ChEBI ID
CHEBI:17697
CAS Number
CAS 1210-83-9
TTD Drug ID
DMJ4SBM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Melatonin receptor type 1A (MTNR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [4]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [5]
Tasimelteon DMLOQ1V Insomnia 7A00-7A0Z Approved [6]
Neu-P11 DMIQDFW Alzheimer disease 8A20 Phase 2 [7]
LY-156735 DM5IX9M Anxiety disorder 6B00-6B0Z Phase 2 [8]
Agomelatine DMXYA5K Major depressive disorder 6A70.3 Withdrawn from market [9]
Luzindole DMXRJQV Sleep-wake disorder 7A00-7B2Z Terminated [10]
S-20928 DMQDWMJ Sleep-wake disorder 7A00-7B2Z Terminated [11]
GR-133347 DMNRJA0 Anxiety disorder 6B00-6B0Z Terminated [12]
GR-131663 DMKAGLV Anxiety disorder 6B00-6B0Z Terminated [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melatonin receptor type 1A (MTNR1A) TT0WAIE MTR1A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
UDP-glucuronosyltransferase 1-6 OTGTQ2C9 UD16_HUMAN Biotransformations [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5451).
2 Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. J Med Chem. 1996 Aug 2;39(16):3089-95.
3 Inhibition of cytochrome P450 enzymes and uridine 5'-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions. Chem Biol Interact. 2022 Jan 25;352:109775. doi: 10.1016/j.cbi.2021.109775. Epub 2021 Dec 12.
4 The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8.
5 MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J Med Chem. 2014 Apr 24;57(8):3161-85.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393).
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 288).
8 Melatonin and sleep in aging population. Exp Gerontol. 2005 Dec;40(12):911-25.
9 Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68.
10 Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10.
11 Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6.
12 US patent application no. 5,151,446, Substituted 2-amidotetralins as melatonin agonists and antagonists.
13 Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur J Pharmacol. 1999 Oct 15;382(3):157-66.