Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ6PB8)

• Drug Name: ETHYLGALLATE Drug Info
• Synonyms: ETHYL GALLATE; 831-61-8; Ethyl 3,4,5-trihydroxybenzoate; Gallic acid ethyl ester; Phyllemblin; Nipagallin A; Progallin A; Ethylgallate; Nipa No. 48; Gallic acid, ethyl ester; Benzoic acid, 3,4,5-trihydroxy-, ethyl ester; NIPA 48; 3,4,5-Trihydroxybenzoic acid ethyl ester; Ethyl-3,4,5-trihydroxybenzoate; Ethylester kyseliny gallove; UNII-235I6UDD3L; NSC 402626; Ethylester kyseliny gallove [Czech]; EINECS 212-608-5; BRN 2116014; CHEMBL453196; 235I6UDD3L; CHEBI:87247; VFPFQHQNJCMNBZ-UHFFFAOYSA-N; NSC402626; AK-94174; Q-100846; Gallic aci

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 13250
  ChEBI ID: CHEBI:87247
  CAS Number: CAS 831-61-8
  TTD Drug ID: DMJ6PB8
  INTEDE Drug ID: DR2373

Molecule-Related Drug Atlas

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[3]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[4]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[5]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[4]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[6]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[1]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[1]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[1]

Drug(s) Metabolized By Glucansucrase (gtf106B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sucrose	DMVWUCF	Discovery agent	N.A.	Investigative	[7]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[8]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[9]
PYROGALLOL	DMG5KDY	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glucansucrase (gtf106B) Main DME	DEWRN24	Q5SBN3_LACRE	Substrate	[2]

References

• [1] Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.
• [2] Exploring the effects of plant odors, from tree species of differing host quality, on the response of Lymantria dispar males to female sex pheromones. J Chem Ecol. 2017 Mar;43(3):243-253.
• [3] Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.
• [4] Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.
• [5] Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.
• [6] Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50.
• [7] Biosolids application affects the competitive sorption and lability of cadmium, copper, nickel, lead, and zinc in fluvial and calcareous soils. Environ Geochem Health. 2017 Dec;39(6):1365-1379.
• [8] Increased infections with beta-blocker use in ischemic stroke, a beta2-receptor mediated process? Neurol Sci. 2017 Jun;38(6):967-974.
• [9] Catechol glucosides act as donor/acceptor substrates of glucansucrase enzymes of Lactobacillus reuteri. Appl Microbiol Biotechnol. 2017 Jun;101(11):4495-4505.
• [10] Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci. 2017 May;32(4):827-832.