Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJL1MB)

Drug Name
67S Drug Info
Synonyms CHEMBL3814206; {2-[(2r)-4-[4-(Hydroxymethyl)-3-(Methylsulfonyl)phenyl]-2-(Propan-2-Yl)piperazin-1-Yl]-4-(Trifluoromethyl)pyrimidin-5-Yl}methanol; SCHEMBL17519333; BDBM50177015; 67S
Cross-matching ID
PubChem CID
91827457
TTD Drug ID
DMJL1MB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9073931, E2 DMK9FJG N. A. N. A. Patented [2]
BDBM50177019 DMEL28G N. A. N. A. Patented [1]
US9006244, E2b DMP0TBO N. A. N. A. Patented [3]
US9073931, E1 DM2Z43I N. A. N. A. Patented [2]
US9006244, E1 DMBF1C0 N. A. N. A. Patented [3]
BDBM50177012 DM52IQF N. A. N. A. Patented [1]
US9006244, E2a DMPDF9B N. A. N. A. Patented [3]
US9073931, E3 DMCYM8P N. A. N. A. Patented [2]
desmosterol DMV8SUM Discovery agent N.A. Investigative [4]
L-783483 DM6OTGE Discovery agent N.A. Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxysterols receptor LXR-alpha (NR1H3) TTECBXN NR1H3_HUMAN Inhibitor [1]

References

1 Piperazine derivatives as liver X receptor modulators. US10144715.
2 Liver X receptor modulators. US9073931.
3 Liver X receptor modulators. US9006244.
4 Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.
5 A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.