Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJV2IF)

• Drug Name: JCAR017 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[1]
leukaemia	2A60-2B33	Phase 1/2	[2]
B-cell non-hodgkin lymphoma	2B33.5	Phase 1	[3]
Follicular lymphoma	2A80	Phase 1	[4]
Mantle cell lymphoma	2A85.5	Phase 1	[1]
Non-hodgkin lymphoma	2B33.5	Phase 1	[1]
Primary mediastinal B-cell lymphoma	2A81	Phase 1	[4]
Multiple myeloma	2A83	Clinical trial	[1]

• Cross-matching ID: TTD Drug ID: DMJV2IF

Molecule-Related Drug Atlas

Drug(s) Targeting B-lymphocyte surface antigen B4 (CD19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tisagenlecleucel	DMM9BJD	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Blinatumomab	DMGECIJ	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Axicabtagene ciloleucel	DMYHN59	Diffuse large B-cell lymphoma	2A81	Approved	[7]
Lisocabtagene maraleucel	DMP45ME	Large B-cell lymphoma	2A81	Approved	[8]
Inebilizumab	DMI0RHA	Neuromyelitis optica spectrum disorder	8E4A.0	Approved	[9]
Tecartus	DMYQCWT	Mantle cell lymphoma	2A85.5	Approved	[10]
Loncastuximab tesirine	DMXSVGI	Diffuse large B-cell lymphoma	2A81	Approved	[11]
Obexelimab	DMVIC4J	IgG4 related disease	4A43.0	Phase 3	[12]
MOR-208	DMDQOWT	Diffuse large B-cell lymphoma	2A81	Phase 2/3	[13]
CART-19	DMST3FM	Acute lymphoblastic leukaemia	2A85	Phase 2/3	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-lymphocyte surface antigen B4 (CD19)	TTW640A	CD19_HUMAN	CAR-T-Cell-Therapy	[1]

References

• [1] ClinicalTrials.gov (NCT03436771) Long-term Follow-up Study for Patients Previously Treated With a Juno CAR T-Cell Product
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041076)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] ClinicalTrials.gov (NCT02631044) Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001)
• [5] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [6] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [9] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [10] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [11] Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma. Blood. 2021 May 13;137(19):2634-2645.
• [12] Emerging B-Cell Therapies in Systemic Lupus Erythematosus. Ther Clin Risk Manag. 2021 Jan 14;17:39-54.
• [13] A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL. Blood. 2014 Dec 4;124(24):3553-60.
• [14] ClinicalTrials.gov (NCT03027739) CART-19 Cells For MRD Positive CD19+ ALL