Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKCBSM)

Drug Name

SOM3355 Drug Info

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Synaptic vesicle amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deutetrabenazine	DMUPFLI	Huntington disease	8A01.10	Approved	[3]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[4]
Tetrabenazine	DMYWQ0O	Huntington disease	8A01.10	Approved	[4]
Alseroxylon	DMB47TQ	Hypertension	BA00-BA04	Approved	[5]
Valbenazine Tosylate	DMQSA2V	Tardive dyskinesia	8A02.10	Approved	[3]
Alkavervir	DMB4HFI	High blood pressure	BA00	Approved	[3]
Ingrezza	DMVPLNC	Tardive dyskinesia	8A02.10	Phase 4	[6]
NBI-98854	DMVO1C0	Movement disorder	8A07-8A0Z	Phase 3	[7]
AV 133	DM0EQ9X	Alzheimer disease	8A20	Phase 3	[8]
Lobeline	DMT3KB4	Substance use disorder	6C4Z	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Synaptic vesicle amine transporter (SLC18A2)	TTNZRI3	VMAT2_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03575676) Efficacy and Safety of SOM3355 in Huntington's Disease Chorea. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. J Neurosci. 2009 Jul 1;29(26):8530-8.
5	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
6	VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine). Prog Med Chem. 2018;57(1):87-111.
7	NBI-98854, a selective monoamine transport inhibitor for the treatment of tardive dyskinesia: A randomized, double-blind, placebo-controlled study. Mov Disord. 2015 Oct;30(12):1681-7.
8	Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET. PLoS One. 2013 Sep 30;8(9):e75952.
9	Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Curr Top Med Chem. 2011;11(9):1103-27.