Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKGQF0)

Drug Name

Suvodirsen Drug Info

Synonyms

WVE-210201

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 2/3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Dystrophin messenger RNA (DMD mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eteplirsen	DM2QBHP	Duchenne dystrophy	8C70	Approved	[3]
GSK2402968	DMWL2XD	Duchenne dystrophy	8C70	Phase 3	[4]
Drisapersen	DMWUN1S	Duchenne dystrophy	8C70	Phase 3	[5]
PRO-044	DMFYABR	Duchenne dystrophy	8C70	Phase 2	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dystrophin messenger RNA (DMD mRNA)	TTWLFXU	DMD_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03907072) Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy (DYSTANCE 51). U.S. National Institutes of Health.
2	Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694.
3	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
4	Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study. Lancet Neurol. 2014 Oct;13(10):987-96.
5	PRO-051, an antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy. Curr Opin Mol Ther. 2010 Aug;12(4):478-86.
6	Update on neuromuscular disorders in pediatric orthopaedics: Duchenne muscular dystrophy, myelomeningocele, and cerebral palsy. J Pediatr Orthop. 2014 Oct-Nov;34 Suppl 1:S44-8.