Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML3M0O)

Drug Name

TAK-701 Drug Info

Synonyms

SCHEMBL131582

Indication

Disease Entry	ICD 11	Status	REF
Advanced malignancy	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VM-202	DMSW80U	Angina pectoris	BA40	Phase 3	[3]
Donaperminogene seltoplasmid	DMH8IT5	Diabetic foot ulcer	BD54	Phase 3	[4]
ANG-3777	DMGP8WX	Delayed graft function	4B24.0	Phase 3	[5]
Ficlatuzumab	DMG65WH	Multiple myeloma	2A83	Phase 2	[6]
Collategene	DM27H0P	Peripheral Ischemic Ulcers	BD41	Phase 2	[7]
MP0250	DMR3VCY	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[6]
ABI-011	DM1KD7U	Lymphoma	2A80-2A86	Phase 1	[6]
Rilotumumab	DMD8ZSW	Grade IV malignant glioma	2A00.0	Discontinued in Phase 2	[8]
N,O6-Disulfo-Glucosamine	DMYCV7U	Discovery agent	N.A.	Investigative	[9]
O2-Sulfo-Glucuronic Acid	DME78MS	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatocyte growth factor (HGF)	TT4V2JM	HGF_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00831896) Phase I Study of TAK-701 in Adult Patients With Advanced Nonhematological Malignancies. U.S. National Institutes of Health.
2	Targeting MET in cancer: rationale and progress.Nat Rev Cancer.2012 Jan 24;12(2):89-103.
3	Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model. Eur J Cardiothorac Surg. 2008 Oct;34(4):857-63.
4	Clinical pipeline report, company report or official report of ViroMed.
5	Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery-Associated Acute Kidney Injury. Kidney Int Rep. 2020 Sep 25;5(12):2325-2332.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Ther. 2010 Sep;17(9):1152-61.
8	Clinical pipeline report, company report or official report of Amgen (2009).
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.