General Information of Drug (ID: DML6QJN)

Drug Name
SDZ-MKS-492 Drug Info
Synonyms MKS-492
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Phase 1 [1]
Cross-matching ID
PubChem CID
163931
CAS Number
CAS 114606-56-3
TTD Drug ID
DML6QJN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Phosphodiesterase 3 (PDE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [2]
Oxtriphylline DMLHSE3 Cough MD12 Approved [2]
Ibudilast DM4LSPN Castleman's disease 4B2Y Approved [3]
Enoximone DMQVZJD Congestive heart failure BD10 Approved [4]
Olprinone DMWBQKU Heart failure BD10-BD13 Approved [5]
Inamrinone Lactate DMRMFP4 Cardiac disease BA00-BE2Z Approved [6]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [2]
Tofisopam DMTGNWU Hyperuricaemia 5C55.Y Phase 2 [7]
Tipelukast DMS9BDQ Asthma CA23 Phase 2 [8]
RPL-554 DMLD4VQ Allergic rhinitis CA08.0 Phase 2 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 3 (PDE3) TTZCG4L NOUNIPROTAC Modulator [1]

References

1 Effects of a cyclic nucleotide phosphodiesterase isoenzyme type III inhibitor, SDZ MKS 492 on airway responsiveness in beagles. Arerugi. 1993 Aug;42(8):920-5.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nat Rev Drug Discov. 2019 Oct;18(10):770-796.
4 In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine. Anesthesiology. 2003 Apr;98(4):944-9.
5 Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev. 2002 Fall;20(3):163-74.
6 Effects of amrinone on hepatic ischemia-reperfusion injury in rats. J Hepatol. 2002 Jul;37(1):31-8.
7 The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25.
8 Company report (MediciNova)
9 Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.Lancet Respir Med.2013 Nov;1(9):714-27.