Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML70NC)

Drug Name
aza-THIP Drug Info
Synonyms
654666-65-6; 1,2,4,5,6,7-Hexahydro-3H-pyrazolo[3,4-c]pyridin-3-one; 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol; 3H-Pyrazolo[3,4-c]pyridin-3-one, 1,2,4,5,6,7-hexahydro-; 1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-3-ol; 4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridin-3-ol; aza-THIP; THIP, Aza-; 4,5,6,7-tetrahydropyrazolo[5,4-c]pyridin-3-ol; SCHEMBL2946381; GTPL4143; SCHEMBL16057201; CTK1J6712; BDBM86256; DTXSID20717441; UPMMUUFLHUEUKP-UHFFFAOYSA-N; MolPort-022-468-866; ZINC13859300; AKOS022182337; AKOS022718659; AKOS006351664
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
55285412
CAS Number
CAS 654666-65-6
TTD Drug ID
DML70NC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor rho3 (GABRR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TBPS DMFC3XP Discovery agent N.A. Investigative [4]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [4]
piperidine-4-sulphonic acid DMMIZWE Discovery agent N.A. Investigative [4]
trans-3-ACPBPA DM6HI8W Discovery agent N.A. Investigative [4]
cis-3-ACPBPA DMQ0EA7 Discovery agent N.A. Investigative [4]
5-Me-IAA DMFZN7J Discovery agent N.A. Investigative [4]
TPMPA DMBF6KS Discovery agent N.A. Investigative [4]
(+/-)-cis-2-CAMP DMY3J0B Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting GABA(A) receptor rho2 (GABRR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TBPS DMFC3XP Discovery agent N.A. Investigative [3]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [3]
piperidine-4-sulphonic acid DMMIZWE Discovery agent N.A. Investigative [3]
trans-3-ACPBPA DM6HI8W Discovery agent N.A. Investigative [3]
cis-3-ACPBPA DMQ0EA7 Discovery agent N.A. Investigative [3]
5-Me-IAA DMFZN7J Discovery agent N.A. Investigative [3]
TPMPA DMBF6KS Discovery agent N.A. Investigative [3]
(+/-)-cis-2-CAMP DMY3J0B Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting GABA(A) receptor rho1 (GABRR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TBPS DMFC3XP Discovery agent N.A. Investigative [2]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [2]
piperidine-4-sulphonic acid DMMIZWE Discovery agent N.A. Investigative [2]
trans-3-ACPBPA DM6HI8W Discovery agent N.A. Investigative [2]
cis-3-ACPBPA DMQ0EA7 Discovery agent N.A. Investigative [2]
5-Me-IAA DMFZN7J Discovery agent N.A. Investigative [2]
TPMPA DMBF6KS Discovery agent N.A. Investigative [2]
(+/-)-cis-2-CAMP DMY3J0B Discovery agent N.A. Investigative [2]
CACA DMPKFYZ Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor rho1 (GABRR1) TT6XFEU GBRR1_HUMAN Antagonist [2]
GABA(A) receptor rho2 (GABRR2) TTQMXLS GBRR2_HUMAN Antagonist [3]
GABA(A) receptor rho3 (GABRR3) TT4N6D8 GBRR3_HUMAN Antagonist [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4143).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422).
5 Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists. Mol Pharmacol. 1993 Apr;43(4):609-25.