Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML73BR)

Drug Name

U-96988 Drug Info

Synonyms

U-96988; CHEMBL22164; PNU-96988; AC1LA3LC; BDBM770; SCHEMBL6173602; 149394-65-0; U96988; 6-(1-benzylpropyl)-4-hydroxy-3-(1-phenylpropyl)pyran-2-one; 2-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl)pyran-4-one

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 54686718
TTD Drug ID: DML73BR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[3]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[5]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[6]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[7]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[8]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[9]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[10]
BI 201335	DM3MXT8	Hepatitis C virus infection	1E51.1	Phase 3	[11]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004387)
2	Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors. J Med Chem. 1994 Sep 30;37(20):3200-4.
3	PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
4	Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
5	Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
6	Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
7	Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
8	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
11	2011 Pipeline of Boehringer Ingelheim Pharma.
12	2011 Pipeline of Bristol-Myers Squibb.