General Information of Drug (ID: DMLA3P1)

Drug Name
EUK-207 Drug Info
Indication
Disease Entry ICD 11 Status REF
Neurodegenerative disorder 8A20-8A23 Terminated [1]
Cross-matching ID
PubChem CID
135469150
TTD Drug ID
DMLA3P1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tofersen DM0AEDT Amyotrophic lateral sclerosis 8B60.0 Approved [2]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [3]
Tempol DMUQH78 Spinal cord injury ND51.2 Phase 2 [4]
Superoxide dismutase DMSWPA6 Myocardial infarction BA41-BA43 Phase 2 [5]
Midismase DMGCRKY Cerebral infarction 8B11.5Z Phase 2 [6]
Methoxyestradiol DMHSL87 N. A. N. A. Phase 2 [7]
ATN-224 DMQJ5DV Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
PC-SOD DMUHDX3 Interstitial lung disease CB0Z Phase 2 [6]
APN-201 DMV7Q6X Dermatitis EA80-EA89 Phase 1/2 [8]
EUK-189 DMY9ZAS Skin burns ME65.0 Phase 1 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn) TT6RVLG SODC_HUMAN Modulator [1]

References

1 A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin. J Invest Dermatol. 2013 Apr;133(4):1088-96.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
4 The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):29-34.
5 Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36.
6 A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis
7 Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem. 2003 Jan 3;278(1):407-14.
8 Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59.
9 Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.