Details of the Drug

General Information of Drug (ID: DMA0WEK)

Drug Name
Coprexa
Synonyms Tetrathiomolybdate
Indication
Disease Entry ICD 11 Status REF
Neurological disorder 6B60 Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 226.2
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 0
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Chemical Identifiers
Formula
H2MoS4-2
IUPAC Name
bis(sulfanylidene)molybdenum;sulfanide
Canonical SMILES
[SH-].[SH-].S=[Mo]=S
InChI
InChI=1S/Mo.2H2S.2S/h;2*1H2;;/p-2
InChIKey
VVRHUOPINLMZBL-UHFFFAOYSA-L
Cross-matching ID
PubChem CID
5245480
ChEBI ID
CHEBI:30703
CAS Number
16330-92-0
TTD ID
D06WPM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn) TT6RVLG SODC_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [2]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [3]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Gene/Protein Processing [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Aquaporin-1 (AQP1) OTX5MYX9 AQP1_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Gene/Protein Processing [4]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Gene/Protein Processing [4]
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) OTREV92I CEAM5_HUMAN Gene/Protein Processing [2]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) OTQOUHVK CEAM6_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
2 Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
3 The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann N Y Acad Sci. 2004 Dec;1035:34-48. doi: 10.1196/annals.1332.003.
4 Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. Microvasc Res. 2009 May;77(3):314-26.