Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLDHMB)

Drug Name
2,5-Anhydroglucitol-1,6-Biphosphate Drug Info
Synonyms
2,5-Anhydroglucitol-1,6-Biphosphate; 2,5-Anhydro-D-glucitol-1,6-diphosphate; 2,5-Anhydro-D-glucitol 1,6-diphosphate; 4429-47-4; AHG; 2,5-Anhydroglucitol 1,6-Bisphosphate; AC1L9I6X; SCHEMBL20154711; ZINC3870733; AKOS032954084; DB02778; 2,5-anhydro-1,6-di-O-phosphono-D-glucitol; 2,5-Anhydro-D-glucitol 1,6-bisphosphoric acid; W-202770; [(2R,3S,4S,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]methyl dihydrogen phosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
445555
TTD Drug ID
DMLDHMB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fructose-1,6-bisphosphatase (FBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Managlinat dialanetil DMBYDNE Type-2 diabetes 5A11 Phase 2 [2]
MB07803 DMHU8SJ Type-2 diabetes 5A11 Phase 2 [3]
4,6-Dichloro-1H-indole-2-carboxylic acid DM62XC3 Discovery agent N.A. Investigative [4]
4-(2-amino-1,3-thiazol-4-yl)phenol DMH5CAQ Discovery agent N.A. Investigative [5]
Fructose-6-Phosphate DMU5SAF Discovery agent N.A. Investigative [1]
1-(4-aminophenylsulfonyl)-3-(2-mercaptoethyl)urea DM4G0NH Discovery agent N.A. Investigative [6]
1-(2-mercaptoethyl)-3-(m-tolylsulfonyl)urea DMIPAMW Discovery agent N.A. Investigative [6]
4-(4-(4-Nitrophenyl)thiazol-2-ylamino)phenol DMA9TCD Discovery agent N.A. Investigative [5]
3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol DM8EH07 Discovery agent N.A. Investigative [5]
2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol DMOYT8I Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fructose-1,6-bisphosphatase (FBP) TTWHDVK F16P1_HUMAN; F16P2_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5 A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22.
6 Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12.