Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLFJHE)

• Drug Name: Pycnogenol Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMLFJHE

Molecule-Related Drug Atlas

Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[2]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[3]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[4]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[5]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[5]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
CAT 1004	DMQBP7R	Duchenne dystrophy	8C70	Phase 2	[7]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[8]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[9]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Inhibitor	[1]

References

• [1] Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann N Y Acad Sci. 2001 Apr;928:141-56.
• [2] Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
• [3] Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene. 2001 Nov 29;20(55):8009-18.
• [4] Reduced astrocytic NF- B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep;124(3):411-24.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Auckland Cancer Society Research Centre report
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 3;201(1):105-15.
• [9] DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood). 2008 Feb;233(2):180-91.
• [10] US patent application no. US20100278784 A1.