Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLGD0V)

• Drug Name: PF-04776548 Drug Info
• Synonyms: PF-04776548 (oral, HIV infection)

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 90666167
  TTD Drug ID: DMLGD0V

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[2]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[3]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[4]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[5]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[6]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[7]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[8]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[9]
BI 201335	DM3MXT8	Hepatitis C virus infection	1E51.1	Phase 3	[10]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Modulator	[1]

References

• [1] ClinicalTrials.gov (NCT01045317) A Study To Investigate The Clearance Of PF-04776548 From The Body Following A Very Low (Micro) Dose Of The Compound Using A Low Level Of Radiotracer To Help Quantify Expected Low Concentrations Of PF-04776548 In The Body. U.S. National Institutes of Health.
• [2] PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
• [3] Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
• [4] Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
• [5] Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
• [6] Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
• [7] 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [9] Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
• [10] 2011 Pipeline of Boehringer Ingelheim Pharma.
• [11] 2011 Pipeline of Bristol-Myers Squibb.