Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLPAFG)

• Drug Name: CD19-targeted CAR-T cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Clinical trial	[1]
Lymphoma	2A80-2A86	Clinical trial	[2]

• Cross-matching ID: TTD Drug ID: DMLPAFG

Molecule-Related Drug Atlas

Drug(s) Targeting B-lymphocyte surface antigen B4 (CD19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tisagenlecleucel	DMM9BJD	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Blinatumomab	DMGECIJ	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Axicabtagene ciloleucel	DMYHN59	Diffuse large B-cell lymphoma	2A81	Approved	[5]
Lisocabtagene maraleucel	DMP45ME	Large B-cell lymphoma	2A81	Approved	[6]
Inebilizumab	DMI0RHA	Neuromyelitis optica spectrum disorder	8E4A.0	Approved	[7]
Tecartus	DMYQCWT	Mantle cell lymphoma	2A85.5	Approved	[8]
Loncastuximab tesirine	DMXSVGI	Diffuse large B-cell lymphoma	2A81	Approved	[9]
Obexelimab	DMVIC4J	IgG4 related disease	4A43.0	Phase 3	[10]
MOR-208	DMDQOWT	Diffuse large B-cell lymphoma	2A81	Phase 2/3	[11]
CART-19	DMST3FM	Acute lymphoblastic leukaemia	2A85	Phase 2/3	[12]
Tisagenlecleucel	DMM9BJD	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Blinatumomab	DMGECIJ	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Axicabtagene ciloleucel	DMYHN59	Diffuse large B-cell lymphoma	2A81	Approved	[5]
Lisocabtagene maraleucel	DMP45ME	Large B-cell lymphoma	2A81	Approved	[6]
Inebilizumab	DMI0RHA	Neuromyelitis optica spectrum disorder	8E4A.0	Approved	[7]
Tecartus	DMYQCWT	Mantle cell lymphoma	2A85.5	Approved	[8]
Loncastuximab tesirine	DMXSVGI	Diffuse large B-cell lymphoma	2A81	Approved	[9]
Obexelimab	DMVIC4J	IgG4 related disease	4A43.0	Phase 3	[10]
MOR-208	DMDQOWT	Diffuse large B-cell lymphoma	2A81	Phase 2/3	[11]
CART-19	DMST3FM	Acute lymphoblastic leukaemia	2A85	Phase 2/3	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-lymphocyte surface antigen B4 (CD19)	TTW640A	CD19_HUMAN	CAR-T-Cell-Therapy	[2]

References

• [1] ClinicalTrials.gov (NCT03564977) CD19-targeted CAR-T Cell Therapy for MRD+ B-cell Malignancies After Autologous Stem Cell Transplantation
• [2] ClinicalTrials.gov (NCT02728882) Study Evaluating the Efficacy and Safety With CAR-T for Recurrent or Refractory Diffuse Large B Cell Lymphoma
• [3] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [4] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [9] Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma. Blood. 2021 May 13;137(19):2634-2645.
• [10] Emerging B-Cell Therapies in Systemic Lupus Erythematosus. Ther Clin Risk Manag. 2021 Jan 14;17:39-54.
• [11] A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL. Blood. 2014 Dec 4;124(24):3553-60.
• [12] ClinicalTrials.gov (NCT03027739) CART-19 Cells For MRD Positive CD19+ ALL