General Information of Drug (ID: DMLXOAQ)

Drug Name
PMID23639540C13a Drug Info
Synonyms 1435615-18-1; GTPL8155; KS-00000UBW; MolPort-044-728-919; ZINC96270778; BDBM50434751; AKOS032946391; AK687595
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
60182393
TTD Drug ID
DMLXOAQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
INCB00928 DMFG8TI Anemia 3A00-3A9Z Phase 2 [2]
TP-0184 DMJVZBC Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
PMID27774822-Compound-Figure10Compound12 DMFAGOZ N. A. N. A. Patented [4]
PMID27774822-Compound-Figure10Compound4 DMMJVTW N. A. N. A. Patented [4]
PMID23639540C13d DMSTQGH Discovery agent N.A. Investigative [1]
PMID23639540C13r DMHBZ0N Discovery agent N.A. Investigative [1]
LDN-214117 DM57Z8J Discovery agent N.A. Investigative [5]
ML347 DMR8N36 Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-03446962 DMTJWNE Solid tumour/cancer 2A00-2F9Z Phase 2 [6]
PMID23639540C13d DMSTQGH Discovery agent N.A. Investigative [1]
PMID23639540C13r DMHBZ0N Discovery agent N.A. Investigative [1]
LDN-214117 DM57Z8J Discovery agent N.A. Investigative [5]
ML347 DMR8N36 Discovery agent N.A. Investigative [1]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acadesine DM1RMF5 Diabetic complication 5A2Y Phase 3 [7]
MB-11055 DM3RBJW Fatty liver disease DB92.Z Phase 2 [8]
Imeglimin DMMQFG2 Diabetic complication 5A2Y Phase 2 [9]
PXL-770 DMNSRY7 Non-alcoholic fatty liver disease DB92 Phase 2 [10]
ENERGI-F701 DMMIHSO Alopecia ED70 Phase 2 [11]
O-304 DMXM34I Type 2 diabetes 5A11 Phase 2 [12]
IM156 DM4MY9C Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
Phenformin DMQ52JG Diabetic complication 5A2Y Withdrawn from market [14]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [15]
SU 6656 DMF1P6W Discovery agent N.A. Investigative [16]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TGF-BR2 mab DMWBQ2Z Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
PMID23639540C13d DMSTQGH Discovery agent N.A. Investigative [1]
PMID16539403C15b DMU2X59 Discovery agent N.A. Investigative [18]
LY2109761 DMAWTG3 Discovery agent N.A. Investigative [19]
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID23639540C13d DMSTQGH Discovery agent N.A. Investigative [1]
PMID23639540C13r DMHBZ0N Discovery agent N.A. Investigative [1]
LDN-214117 DM57Z8J Discovery agent N.A. Investigative [5]
ML347 DMR8N36 Discovery agent N.A. Investigative [1]
AA-184 DMCN4ZD Kidney injury NB92.0 Investigative [20]
AA-204 DMBGTX9 Kidney disease GC2Z Investigative [20]
AA-123 DMW73A8 Prostate cancer 2C82.0 Investigative [20]
AA-166 DM2BMAZ Articular cartilage disorder FA34.Y Investigative [20]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [21]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [22]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [23]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [24]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [25]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [26]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [27]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [28]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [29]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [30]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Activin receptor-like kinase 2 (ALK-2) TTJNBQA ACVR1_HUMAN Inhibitor [1]
Activin receptor-like kinase-1 (ACVRL1) TTGYPTC ACVL1_HUMAN Inhibitor [1]
AMP-activated protein kinase (AMPK) TTLAFZV AAPK1_HUMAN; AAKB1_HUMAN; AAKG1_HUMAN Inhibitor [1]
Bone morphogenetic protein receptor (BMPR2) TTGKF90 BMPR2_HUMAN Inhibitor [1]
TGF-beta receptor type II (TGFBR2) TTZE3P7 TGFR2_HUMAN Inhibitor [1]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [1]

References

1 Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
2 Clinical pipeline report, company report or official report of Incyte.
3 Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma.
4 Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161.
5 Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.
6 ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood. 2011 June 30; 117(26): 6999-7006.
7 Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother. 2008 Aug;9(12):2137-44.
8 Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.Mol Pharmacol.2007 Jul;72(1):62-72.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032542)
10 Clinical pipeline report, company report or official report of Poxel SA.
11 Clinical pipeline report, company report or official report of Energenesis Biomedical.
12 Clinical pipeline report, company report or official report of Betagenon.
13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
14 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59.
15 Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
16 The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
17 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1795).
18 Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity vers... J Med Chem. 2006 Mar 23;49(6):2138-42.
19 LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-40.
20 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794).
21 Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40.
22 Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93.
23 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
24 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
25 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
26 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
27 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
28 Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45.
29 Clinical pipeline report, company report or official report of Exelixis (2011).
30 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services