Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMU6WQ)

Drug Name

Tetrahydro-pyrimidin-2-ylideneamine Drug Info

Synonyms

1,4,5,6-tetrahydropyrimidin-2-amine; 41078-65-3; 1,4,5,6-tetrahydro-2-Pyrimidinamine; 1,4,5,6-tetrahydro-pyrimidin-2-ylamine; 2-amino-1,4,5,6-tetrahydropyrimidine; CHEMBL158626; Tetrahydro-pyrimidin-2-ylideneamine; Tetrahydropyrimidinimin; 2(1h)-pyrimidinimine; AC1MMKIU; tetrahydro-2(1H)-pyrimidinimine; DTXSID90391075; PEHDFSFYZKSKGH-UHFFFAOYSA-N; ZINC1728936; hexahydro-pyrimidin-2-ylidene-amine; BDBM50049248; AKOS024618750; AKOS011559938; MCULE-1407334516; 2-amino-3,4,5,6-tetrahydropyrimidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3287412
CAS Number: CAS 41078-65-3
TTD Drug ID: DMMU6WQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Nitric-oxide synthase brain (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[2]
NXN-462	DMWVBS2	Headache	8A80-8A84	Phase 2	[3]
L-NIL	DM6Y49D	N. A.	N. A.	Terminated	[4]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[5]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[5]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[5]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[6]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[5]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[5]
6-isobutyl-4-methylpyridin-2-amine	DM2XB68	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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References

1	2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT01748877) Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia. U.S. National Institutes of Health.
4	Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
7	Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53.