Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNAJGK)

• Drug Name: MK-0963 Drug Info
• Synonyms: L-654066; MK-963; (5alpha)-23-Methyl-4-aza-21-norchol-1-ene-3,20-dione; 23-Methyl-21-nor-4-aza-5alpha-chol-1-ene-3,20-dione

Indication

Disease Entry	ICD 11	Status	REF
Prostate disease	GA91	Discontinued in Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 6918127
  CAS Number: CAS 103497-68-3
  TTD Drug ID: DMNAJGK

Molecule-Related Drug Atlas

Drug(s) Targeting Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[3]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[3]
Polyestradiol Phosphate	DM0PMGJ	Prostate cancer	2C82.0	Approved	[4]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[5]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[6]
Epristeride	DM35T1O	Hirsutism	ED72	Phase 3	[7]
FK-143	DMEL15U	Prostate disease	GA91	Phase 2	[8]
Turosteride	DMW7PFS	Prostate disease	GA91	Phase 2	[9]
IZONSTERIDE	DM3KXMG	Hirsutism	ED72	Phase 1/2	[10]
ONO-3805	DM1RKWV	Prostate disease	GA91	Discontinued in Phase 3	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A)	TT2A0DR	S5A1_HUMAN; S5A2_HUMAN; PORED_HUMAN	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003374)
• [2] Pharmacodynamics of MK-0963, a new 5 alpha-reductase inhibitor: effects on serum androgen concentrations. Clin Pharmacol Ther. 1994 Jan;55(1):50-4.
• [3] The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32.
• [6] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [7] Discovery of a novel hybrid from finasteride and epristeride as 5alpha-reductase inhibitor. Bioorg Med Chem Lett. 2011 Jan 1;21(1):475-8.
• [8] FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes. J Steroid Biochem Mol Biol. 1995 Apr;52(4):357-63.
• [9] Hormonal effects of turosteride, a 5 alpha-reductase inhibitor, in the rat. J Steroid Biochem Mol Biol. 1993 Nov;46(5):549-55.
• [10] Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible... Urology. 2004 Jan;63(1):114-9.
• [11] Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-redu... J Androl. 1994 Nov-Dec;15(6):521-7.