Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNEGHJ)

Drug Name

Anthramycin Drug Info

Synonyms

Antramycin; ANTHRAMYCIN; Anthramycin [USAN]; C16H17N3O4; Anthramycin (USAN); Antramycinum [INN-Latin]; Antramycine [INN-French]; Antramicina [INN-Spanish]; Antramycin (INN); Ro 5-9000; 4803-27-4; Antibiotic PBA; (E)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)-benzodiazepine-2-acrylamide; AC1NSJTB; AC1Q5IYM; SCHEMBL4513; CHEMBL39373; 1H-Pyrrolo(2,1-c)(1,4)benzodiazepine-2-acrylamide, 5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-, (E)-; 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihyd

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311005
TTD Drug ID: DMNEGHJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[2]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[3]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[4]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[5]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[6]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[7]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[9]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Not Available	[1]

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References

1	Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. Biochemistry. 1994 Nov 22;33(46):13593-610.
2	Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
3	Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7.
6	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
7	Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32.
8	Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
9	Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21.
10	Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.