Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNJXHF)

Drug Name

Monoisopropyl Ester Phosphonic Acid Group Drug Info

Synonyms

AC1NAQP0; MONOISOPROPYL ESTER PHOSPHONIC ACID GROUP; propan-2-yloxyphosphinic acid; SCHEMBL333601; Phosphonic acid isopropyl ester; AC1O4B47; ZINC5381386

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6383950
TTD Drug ID: DMNJXHF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cytomegalovirus Protease (CMV UL80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10071110, Compound cCDV	DM95YLX	N. A.	N. A.	Patented	[2]
C06909	DMJPW7C	N. A.	N. A.	Patented	[2]
S-(Dimethylarsenic)Cysteine	DMSCHL0	Discovery agent	N.A.	Investigative	[1]
N-(1-PHENYL-PROPYL)-FORMAMIDE	DMSHWYU	Discovery agent	N.A.	Investigative	[3]
O-Benzylsulfonyl-Serine	DMD25HJ	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hexafluronium bromide	DMFY307	Spasm	MB47.3	Approved	[4]
MEPTAZINOL	DMPSB8F	Pain	MG30-MG3Z	Approved	[5]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[6]
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[7]
Plasma derived human butyrylcholinesterase	DMF3IBC	Neurotoxicity	NE61	Phase 1	[8]
Protexia	DME1Y9W	Alzheimer disease	8A20	Phase 1	[9]
JES-9501	DMYR3IE	Alzheimer disease	8A20	Phase 1	[10]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[11]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[11]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]
Cytomegalovirus Protease (CMV UL80)	TT5DOVB	SCAF_HCMVA	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Phosphonate compounds. US10071110.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90.
5	Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
6	Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85.
7	Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
8	Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8.
9	In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5.
10	Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
11	A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.