Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNTDFV)

Drug Name

6-Cl-IMP Drug Info

Synonyms

Hadacidin; N-FORMYL-N-HYDROXYGLYCINE; 689-13-4; Hadacidine; Asymmetrin; Hadacin; Nfhaa; N-Formyl hydroxyaminoacetic acid; UNII-BFO5P1010A; Glycine,N-formyl-N-hydroxy-; 2-(N-Hydroxyformamido)acetic acid; GLYCINE, N-FORMYL-N-HYDROXY-; NSC 72962; BRN 1927168; N-hydroxyformamidoacetic acid; CHEMBL331373; BFO5P1010A; CHEBI:43040; [formyl(hydroxy)amino]acetic acid; NSC 521778; N-formyl-N- hydroxyaminoacetic acid; hadicidine; SCHEMBL2115651; AC1L207A; DTXSID1043962; CTK5C8639; (Formyl-hydroxy-amino)-acetic acid; ZINC1482078

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 12717
ChEBI ID: CHEBI:43040
CAS Number: CAS 689-13-4
TTD Drug ID: DMNTDFV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[4]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[5]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Mizoribine	DMW6F0S	Transplant rejection	NE84	Approved	[5]
Viramidine	DMJFNR9	Hepatitis C virus infection	1E51.1	Phase 3	[7]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
VX-148	DML32R8	Psoriasis vulgaris	EA90	Patented	[9]
PMID28074661-Compound-US20100022547C81	DMM9E1U	N. A.	N. A.	Patented	[8]
PMID28074661-Compound-US20120264760C80	DM75QVW	N. A.	N. A.	Patented	[8]
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Drug(s) Targeting Plasmodium Adenylosuccinate synthetase (Malaria Adss)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[10]
Guanosine-5'-Diphosphate	DM0MUKQ	Discovery agent	N.A.	Investigative	[10]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[10]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[10]
(Carboxyhydroxyamino)Ethanoic Acid	DMZB0C3	Discovery agent	N.A.	Investigative	[10]
(C8-R)-Hydantocidin 5'-Phosphate	DM5WH6R	Discovery agent	N.A.	Investigative	[10]
(C8-S)-Hydantocidin 5'-Phosphate	DMMH179	Discovery agent	N.A.	Investigative	[10]
6-O-Phosphoryl Inosine Monophosphate	DM6YHBR	Discovery agent	N.A.	Investigative	[10]
Hydantocidin-5'-Monophosphate	DMOTXP1	Discovery agent	N.A.	Investigative	[10]
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⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TTL7C8Q	IMDH1_HUMAN	Inhibitor	[2]
Plasmodium Adenylosuccinate synthetase (Malaria Adss)	TTYQ4AE	PURA_PLAFA	Inhibitor	[1]

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References

1	High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12.
2	Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus. Biochemistry. 1995 Oct 24;34(42):13889-94.
3	Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
4	Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
5	VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
6	In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30.
7	Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
8	Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
9	Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.