General Information of Drug (ID: DMNVMB5)

Drug Name
Ac-I[CVTQDWGHHRC]T-NH2 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91933229
TTD Drug ID
DMNVMB5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Complement C3 (CO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pegcetacoplan DM4HQ52 Paroxysmal nocturnal haemoglobinuria 3A21.0 Approved [2]
Imprime PGG DMIUA3M Non-hodgkin lymphoma 2B33.5 Phase 2/3 [3]
POT-4 DMH0LM2 Macular degeneration 9B78.3 Phase 2 [4]
AMY-101 DMS0GA6 Gingivitis DA0B Phase 2 [5]
NGM621 DM84DP5 Geographic atrophy 9B75 Phase 2 [6]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [7]
Ac-I[CV(Bta)QDWGAHRC]T DM5NMVP Discovery agent N.A. Investigative [1]
Ac-I[CVWQDWGWHRC]T-NH2 DMDIUK6 Discovery agent N.A. Investigative [1]
Ac-ICVWQDWGAHRCT-NH2 DMPSI26 Discovery agent N.A. Investigative [8]
Ac-I[CV(Bta)QDWGAHRC]T-NH2 DMFLA5T Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Complement C3 (CO3) TTJGY7A CO3_HUMAN Inhibitor [1]

References

1 Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86.
2 Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.
3 National Cancer Institute Drug Dictionary (drug id 599816).
4 Compstatin: A Complement Inhibitor on its Way to Clinical Application. Adv Exp Med Biol. 2008; 632: 273-292.
5 The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Jun;215:108450.
6 Inhibition of Complement Factor 3 in Geographic Atrophy with NGM621: Phase 1 Dose-Escalation Study Results. Am J Ophthalmol. 2022 Mar;235:131-142.
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8 Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22.