Details of the Drug-Related molecule(s) Interaction Atlas

COSALANE Drug Info

Cosalane; AC1L2I0J; CHEMBL300101; CTK6A7531; BDBM50036146; LS-187298; 5-[1-(3-carboxy-5-chloro-4-hydroxyphenyl)-4-[(3S,10S,13R,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoic acid; 5-{1-(3-carboxy-5-chloro-4-hydroxyphenyl-4-[1-(1,5-dimethylhexyl)-9a,11a-dimethylperhydrocyclopenta[a]phenanthren-7-yl]-1-butenyl}-3-chloro-2-hydroxy acetic acid (Cosalane)

Cross-matching ID

PubChem CID

455040

CAS Number

CAS 154212-56-3

TTD Drug ID

DMO3486

General Information of Drug (ID: DMO3486)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting C-C chemokine receptor type 1 (CCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCX-354	DMSHV9C	Autoimmune diabetes	5A10	Phase 2	[2]
BMS-817399	DMT8L6P	Rheumatoid arthritis	FA20	Phase 2	[3]
AVE1701	DMJY35M	Rheumatoid arthritis	FA20	Phase 1	[4]
AZD4818	DM3VFKM	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[5]
MLN3897	DMRA3EZ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[4]
A-987306	DMU34BK	Discovery agent	N.A.	Investigative	[6]
BX 471	DM5CGXB	Discovery agent	N.A.	Investigative	[7]
Cosalane derivative	DMSFXJ8	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 1 (CCR1)	TTC24WT	CCR1_HUMAN	Inhibitor	[1]

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References

1	Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorg Med Chem Lett. 2001 Jan 8;11(1):59-62.
2	Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis. 2013 Mar;72(3):337-44.
3	Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014 Sep 25;57(18):7550-64.
4	Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
5	Clinical pipeline report, company report or official report of AstraZeneca (2009).
6	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
7	Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.