Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOPUIH)

• Drug Name: PMID15546730C2 Drug Info
• Synonyms: UNII-N9PH4O199D; N9PH4O199D; GTPL8136; BDBM13268

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11153014
  CAS Number: CAS 302961-18-8
  TTD Drug ID: DMOPUIH

Molecule-Related Drug Atlas

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[6]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[6]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[7]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[6]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[8]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Fyn tyrosine protein kinase (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[11]
CEP-5104	DMV43GY	Discovery agent	N.A.	Investigative	[12]
CEP-6331	DMNXBTD	Discovery agent	N.A.	Investigative	[12]
JNJ-10198409	DM9GDP5	Discovery agent	N.A.	Investigative	[13]
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane	DMD7WNV	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Janus kinase 3 (JAK-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[15]
Ritlecitinib	DMYKNME	Alopecia areata	ED70.2	Approved	[16]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[17]
VX-509	DM2U3MX	Rheumatoid arthritis	FA20	Phase 2/3	[18]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[16]
ATI-501	DMTY6OF	Alopecia	ED70	Phase 2	[19]
ATI-502	DM8NODR	Alopecia	ED70	Phase 2	[20]
TD-8236	DMTOMJN	Asthma	CA23	Phase 2	[21]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[22]
SNA-125	DM8L1GJ	Atopic dermatitis	EA80	Phase 1	[16]

Drug(s) Targeting Hematopoietic cell kinase (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BK3	DM6YQO3	N. A.	N. A.	Patented	[23]
Doramapimod	DM6BU7N	Inflammatory bowel disease	DD72	Patented	[24]
3-(6-allyloxy-2-naphthyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine	DM0DYAU	N. A.	N. A.	Patented	[23]
Unii-I92MU0V408	DMUD7H8	N. A.	N. A.	Patented	[24]
US8933228, 3	DMPNCOL	N. A.	N. A.	Patented	[24]
SB19065	DM2MQD0	N. A.	N. A.	Patented	[25]
US9108950, 1	DMPT2ZS	N. A.	N. A.	Patented	[26]
US8933228, Ref 2	DMKEX51	N. A.	N. A.	Patented	[27]
BK7	DMQD4X2	N. A.	N. A.	Patented	[23]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[28]

Drug(s) Targeting Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24900538C2c	DM5PATM	Discovery agent	N.A.	Investigative	[29]

Drug(s) Targeting B lymphocyte kinase (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrazolo[4,3-c]pyridine derivative 2	DMCDFLQ	N. A.	N. A.	Patented	[30]
PMID24915291C38	DMBXT9J	Discovery agent	N.A.	Investigative	[31]
PMID24915291C31	DMN7QB8	Discovery agent	N.A.	Investigative	[31]

Drug(s) Targeting Proto-oncogene c-Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[32]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
AL3818	DM3WP0N	Alveolar soft part sarcoma	2A60-2C35	Phase 3	[34]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[34]
Masitinib	DMRSNEU	Amyotrophic lateral sclerosis	8B60.0	Phase 3	[35]
KX-01	DMF0NA9	Actinic keratosis	EK90.0	Phase 3	[16]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[36]
TPX-0046	DMIVE67	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B lymphocyte kinase (BLK)	TTNDSC3	BLK_HUMAN	Inhibitor	[2]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[2]
Hematopoietic cell kinase (HCK)	TT42OGM	HCK_HUMAN	Inhibitor	[2]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[2]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[2]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[2]
Tyrosine-protein kinase Fgr (FGR)	TTPOGS1	FGR_HUMAN	Inhibitor	[2]

References

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• [15] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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• [31] Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28.
• [32] Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
• [33] In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells. Leuk Res. 1994 Nov;18(11):867-73.
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