Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP26BW)

Drug Name

MX-7065 Drug Info

Synonyms

Cdc25 phosphatase inhibitors, Maxia Pharmaceuticals; MX-7102; MX-7174; MX-7214; MX-7306

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMP26BW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Discontinued Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting M-phase inducer phosphatase 3 (MPIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BN-82685	DMZME4N	Discovery agent	N.A.	Investigative	[3]
BN-82002	DMXY574	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
NSC-663284	DMEXW31	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting M-phase inducer phosphatase 1 (MPIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ro 20-1724	DM0PSCF	Asthma	CA23	Terminated	[5]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	DMJZEMB	Discovery agent	N.A.	Investigative	[6]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	DMQA0EJ	Discovery agent	N.A.	Investigative	[6]
1-dodecyl-1H-indole-2,3-dione	DMK6BWV	Discovery agent	N.A.	Investigative	[7]
3-isopropyl-4-phenylnaphthalene-1,2-dione	DMYZCWX	Discovery agent	N.A.	Investigative	[6]
NSC-95397	DMX0TAM	Discovery agent	N.A.	Investigative	[8]
3-isopropyl-4-(phenylamino)naphthalene-1,2-dione	DMHAJ6W	Discovery agent	N.A.	Investigative	[6]
3-isopropylnaphthalene-1,2-dione	DM46ID2	Discovery agent	N.A.	Investigative	[6]
2-(1-dodecyl-1H-indol-3-yl)acetic acid	DMF2XHZ	Discovery agent	N.A.	Investigative	[7]
(E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid	DMI146O	Discovery agent	N.A.	Investigative	[7]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting M-phase inducer phosphatase 2 (MPIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[10]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[10]
Cysteinesulfonic Acid	DMXI8FP	Discovery agent	N.A.	Investigative	[10]
Cysteine Sulfenic Acid	DM4GZUJ	N. A.	N. A.	Investigative	[11]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	DMJZEMB	Discovery agent	N.A.	Investigative	[6]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	DMQA0EJ	Discovery agent	N.A.	Investigative	[6]
ADOCIAQUINONE B	DMPOU86	Discovery agent	N.A.	Investigative	[12]
3-isopropyl-4-phenylnaphthalene-1,2-dione	DMYZCWX	Discovery agent	N.A.	Investigative	[6]
4-ethoxynaphthalene-1,2-dione	DMUN7KC	Discovery agent	N.A.	Investigative	[9]
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⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
M-phase inducer phosphatase 1 (MPIP1)	TTLZS4Q	MPIP1_HUMAN	Inhibitor	[2]
M-phase inducer phosphatase 2 (MPIP2)	TTR0SWN	MPIP2_HUMAN	Inhibitor	[2]
M-phase inducer phosphatase 3 (MPIP3)	TTESBNC	MPIP3_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016615)
2	Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
3	Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5.
4	Synthesis of small molecule CDC25 phosphatases inhibitors. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.
5	Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61.
6	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
7	Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3.
8	Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4.
9	Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
12	Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.