Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPJ08G)

Drug Name
Cyclopiazonic acid Drug Info
Synonyms
2o9j; 2oa0; BSPBio_001303; GTPL5350; SCHEMBL1471247; MolPort-003-983-745; BS0055; ZINC100061481; ZINC100067111; ZINC110970687; FT-0624278; J-011619; (2R,3S,9R)-5-acetyl-4-hydroxy-8,8-dimethyl-7,16-diazapentacyclo[9.6.1.0^{2,9}.0^{3,7}.0^{15,18}]octadeca-1(17),4,11(18),12,14-pentaen-6-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
54682463
CAS Number
CAS 18172-33-3
TTD Drug ID
DMPJ08G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [3]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [3]
Piperaquine DMT70RC Malaria 1F40-1F45 Approved [3]
Artemisinin SP DMFETDK Malaria 1F40-1F45 Approved [3]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [3]
OZ277 DM1YB0R Malaria 1F40-1F45 Approved [3]
Pyronaridine DMUWAM2 Malaria 1F40-1F45 Approved [3]
Vanadate DMQL0KF Psoriatic arthritis FA21 Phase 3 [2]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5350).
2 Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7.
3 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
4 Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46.