Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPOTM4)

• Drug Name: Sulfatinib Drug Info
• Synonyms: Anticancer agents, Hutchison; HMPL-012; Kinase inhibitors (cancer), Hutchison; VEGFR-1, 2, 3 and FGFR 1 inhibitor (oral, cancer), Hutchison

Indication

Disease Entry	ICD 11	Status	REF
Neuroendocrine cancer	2B72.1	Phase 3	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

• Cross-matching ID:
  PubChem CID: 52920501
  CAS Number: CAS 1308672-74-3
  TTD Drug ID: DMPOTM4

Molecule-Related Drug Atlas

Drug(s) Targeting Vascular endothelial growth factor receptor 3 (FLT-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[5]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Fruquintinib	DMHOSCQ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
PI-88	DMGZPX6	Hepatocellular carcinoma	2C12.02	Phase 3	[8]
Taberminogene vadenovec	DMW5PHL	Vascular restinosis	BE2Z	Phase 3	[9]
ABT-869	DMREDYP	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[11]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
VATALANIB	DMY0UEQ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[13]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[14]

Drug(s) Targeting Macrophage colony-stimulating factor 1 receptor (CSF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[15]
ARRY-382	DM0VGDC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
BLZ-945	DMG1LVA	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[4]
Cabiralizumab	DMGE058	Pancreatic cancer	2C10	Phase 2	[16]
FPA-008	DM3ZN6Y	Autoimmune diabetes	5A10	Phase 1/2	[17]
DCC-3014	DMHW289	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[18]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[4]
TPX-0022	DMC2IJN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
SNDX-6352	DM8ZROW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
DCC-3014	DMLVG9D	Haematological malignancy	2B33.Y	Phase 1	[4]

Drug(s) Targeting Vascular endothelial growth factor receptor (VEGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[20]
Fruquintinib	DMHOSCQ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
KH-902	DM8VO16	Diabetic macular edema	9B71.02	Phase 3	[21]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[22]
BAY-57-9352	DMVA5NS	Gastric adenocarcinoma	2B72	Phase 2	[17]
X-82	DMW1NKO	Age-related macular degeneration	9B75.0	Phase 2	[4]
Vorolanib	DMIM1U9	Non-small cell lung cancer	2C25	Phase 2	[23]
BFH-772	DMVUX1C	Psoriasis vulgaris	EA90	Phase 2	[24]
ASP-8477	DMBZQS7	Neuropathic pain	8E43.0	Phase 2	[25]
AG-013958	DMRET3H	Age-related macular degeneration	9B75.0	Phase 1/2	[26]

Drug(s) Targeting Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[27]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[20]
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[28]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Rosiglitazone + metformin	DMPIDXT	Diabetic complication	5A2Y	Phase 3	[29]
BGJ398	DMNKBEC	Cholangiocarcinoma	2C12.10	Phase 3	[30]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[31]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[32]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
AM-001	DMGVQI8	Actinic keratosis	EK90.0	Phase 2	[33]

Drug(s) Targeting Vascular endothelial growth factor receptor 1 (FLT-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[5]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Fruquintinib	DMHOSCQ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
X-82	DMW1NKO	Age-related macular degeneration	9B75.0	Phase 2	[34]
OCV-101	DMT9QI2	Pancreatic cancer	2C10	Phase 2	[35]
LY3012212	DMRVEHY	Arteriosclerosis	BD40	Phase 2	[36]
OTSGC-A24	DMN0ZQ5	Colorectal cancer	2B91.Z	Phase 1/2	[37]
CEP-11981	DMYDTJ6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
EW-A-401	DM3VC6T	Peripheral vascular disease	BD4Z	Phase 1	[39]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[40]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[27]
Regorafenib	DMHSY1I	Metastatic colorectal cancer	2B91	Approved	[41]
Sunitinib	DMCBJSR	Gastrointestinal cancer	2C11	Approved	[42]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[43]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[44]
Cabozantinib	DMIYDT4	Thyroid cancer	2D10	Approved	[45]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[5]
Lenvatinib	DMB1IU4	Thyroid cancer	2D10	Approved	[46]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibroblast growth factor receptor 1 (FGFR1)	TTRLW2X	FGFR1_HUMAN	Inhibitor	[3]
Macrophage colony-stimulating factor 1 receptor (CSF1R)	TT7MRDV	CSF1R_HUMAN	Inhibitor	[4]
Vascular endothelial growth factor receptor (VEGFR)	TTVJ1D8	NOUNIPROTAC	Inhibitor	[4]
Vascular endothelial growth factor receptor 1 (FLT-1)	TT2Q6G1	VGFR1_HUMAN	Inhibitor	[3]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[3]
Vascular endothelial growth factor receptor 3 (FLT-4)	TTDCBX5	VGFR3_HUMAN	Inhibitor	[3]

References

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