General Information of Drug (ID: DMPOU86)

Drug Name
ADOCIAQUINONE B Drug Info
Synonyms Adociaquinone B
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11201041
TTD Drug ID
DMPOU86

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [3]
4-ethoxynaphthalene-1,2-dione DMUN7KC Discovery agent N.A. Investigative [2]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [4]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [5]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [5]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [5]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [6]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [7]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ Discovery agent N.A. Investigative [7]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [7]
4-ethoxynaphthalene-1,2-dione DMUN7KC Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dual specificity protein phosphatase 1 (DUSP1) TTG8HIM DUS1_HUMAN Inhibitor [2]
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]

References

1 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
2 Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.
3 Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein. Mol Med. 1995 Jul;1(5):535-41.
4 Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.