Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPZTRC)

Drug Name

Ceftazidine Drug Info

Synonyms

Ceftazidine [INN]; Ceftazidine [USAN]; Ceftazidine [IBAN]; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydroxide

Indication

Disease Entry	ICD 11	Status	REF
Meningitis	1D01	Phase 4	[1]

Cross-matching ID

PubChem CID: 13505813
TTD Drug ID: DMPZTRC
INTEDE Drug ID: DR2679

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacterial infection	1A00-1C4Z	Approved	[3]
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[2]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[2]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[3]
Carbapenem	DMXZU73	Cystitis	GC00	Phase 4	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)^{Main DME}	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[2]

------------------------------------------------------------------------------------

References

1	World Health Organization model list of essential medicines: 21st list 2019.
2	Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.
3	A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
4	Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044.