Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ0S4B)

Drug Name
NSC-66209 Drug Info
Synonyms
5407-46-5; Methyl fluorone black; 2,6,7-Trihydroxy-9-methylxanthen-3-one; NSC-66209; 2,6,7-Trihydroxy-9-methyl-xanthen-3-one; NSC 5426; UNII-KQC69H1NAG; KQC69H1NAG; 3H-Xanthen-3-one, 2,6,7-trihydroxy-9-methyl-; MLS000736515; MLS000123248; CHEMBL175266; 2,6,7-trihydroxy-9-methyl-3H-xanthen-3-one; NSC5426; NSC66209; 9-Methyl-2,3,7-trihydroxy-6-fluorone Hemisulfate; ST057760; SMR000123893; BAS 00532150; 9-METHYL-2,3,7-TRIHYDROXY-6-FLUORONE; EINECS 226-468-8; NSC 66209; AC1Q69RP; AC1L2IJ2; cid_72721; SCHEMBL2781454; CTK4J9473
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
72721
CAS Number
CAS 5407-46-5
TTD Drug ID
DMQ0S4B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
AZD5991 DM7QGHO Haematological malignancy 2B33.Y Phase 1 [3]
AMG 176 DM0Q7NO Acute myeloid leukaemia 2A60 Phase 1 [3]
PRT1419 DMIKE0O Melanoma 2C30 Phase 1 [4]
ABBV-467 DM87SM9 Multiple myeloma 2A83 Phase 1 [5]
MIK665 DMTUVCG Acute myeloid leukaemia 2A60 Phase 1 [6]
AMG 397 DM7CNTG Refractory hematologic malignancy 2A85.5 Phase 1 [7]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [8]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [8]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Candida Mannose-6-phosphate isomerase (Candi PMI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfacetamide DMZ6VEY Acne vulgaris ED80 Approved [9]
Sulfoxone DMAYX6P Dermatitis herpetiformis EB44 Approved [9]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [10]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [10]
GNF-PF-5134 DM7850H Discovery agent N.A. Investigative [1]
GNF-PF-2272 DMONK0F Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Mannose-6-phosphate isomerase (Candi PMI1) TT915ZD MPI_CANAL Inhibitor [1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [1]

References

1 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
2 Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of Prelude Therapeutics.
5 Clinical pipeline report, company report or official report of AbbVie.
6 MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443.
7 Clinical pipeline report, company report or official report of Amgen.
8 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.
9 Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54.
10 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.