Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ0X7I)

Drug Name

IOX2 Drug Info

Synonyms

compound 6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting HIF-prolyl hydroxylase 2 (HPH-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FG-4592	DM4XSQ2	Anaemia	3A90	Phase 3	[2]
US9422240, 1-298	DMH7DL5	N. A.	N. A.	Patented	[3]
US8598210, Table XV, 2	DMDK98P	N. A.	N. A.	Patented	[4]
US8536181, A41	DMF9LNO	N. A.	N. A.	Patented	[5]
US8598210, Table XV, 5	DMEU5ST	N. A.	N. A.	Patented	[6]
US8536181, C17	DMRTL63	N. A.	N. A.	Patented	[7]
US8598210, Table XV, 4	DM3XWMO	N. A.	N. A.	Patented	[8]
US8921389, 210	DME1A80	N. A.	N. A.	Patented	[9]
US8536181, C35	DMAM51Z	N. A.	N. A.	Patented	[5]
US10100051, Compound 2	DMWESZ1	N. A.	N. A.	Patented	[10]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Lysine-specific demethylase 2A (KDM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
daminozide	DMXM7JR	Discovery agent	N.A.	Investigative	[11]
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Drug(s) Targeting Lysine-specific demethylase 5C (KDM5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PBIT	DM8Q54I	Discovery agent	N.A.	Investigative	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 2A (KDM2A)	TT8XTY2	KDM2A_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 5C (KDM5C)	TT94UCF	KDM5C_HUMAN	Inhibitor	[1]

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References

1	Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
2	Crystalline forms of a prolyl hydroxylase inhibitor. US9115085.
3	Partially saturated nitrogen-containing heterocyclic compound. US9422240.
4	Prolyl hydroxylase inhibitors and methods of use. US9598370.
5	Prolyl hydroxylase inhibitors. US8536181.
6	Prolyl hydroxylase inhibitors and method of use. US8722895.
7	Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412.
8	Prolyl hydroxylase inhibitors and methods of use. US8598210.
9	Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170.
10	Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051.
11	Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.
12	Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.