Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ6DLZ)

• Drug Name: KF-17837 Drug Info
• Synonyms: CHEMBL27508; (E)-8-(3,4-Dimethoxystyryl)-7-methyl-1,3-dipropylxanthine; 141807-96-7; 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-dipropyl-7-methyl-, (E)-; UQGGPCQNHJCOPS-PKNBQFBNSA-N; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-7-methyl-1,3-dipropylpurine-2,6-dione; AC1O68AZ; SCHEMBL537086; SCHEMBL537085; SCHEMBL9364001; 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione; BDBM50006710; KF-17387; LS-126824; L006852

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 6448585
  CAS Number: CAS 141807-96-7
  TTD Drug ID: DMQ6DLZ

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine A2a receptor (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[4]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[5]
Regadenoson	DM76VHG	Radionuclide imaging	N.A.	Approved	[6]
Tozadenant	DMATC14	Parkinson disease	8A00.0	Phase 3	[7]
Binodenoson	DMVHF8G	Hypertension	BA00-BA04	Phase 3	[8]
Apadenoson	DMD8QTC	Coronary artery disease	BA80	Phase 3	[9]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[10]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[11]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[12]
BIIB014	DMH7RJ1	Parkinson disease	8A00.0	Phase 2	[13]

Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[14]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[14]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[15]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[10]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[16]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[17]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[18]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[19]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[17]
PF-1913539	DMXEU14	Alzheimer disease	8A20	Discontinued in Phase 3	[20]

Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[4]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[21]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[10]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[12]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[22]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[23]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[24]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[22]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[25]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[2]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[3]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[3]

References

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• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3290).
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• [11] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [12] Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53.
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• [14] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [15] Clinical pipeline report, company report or official report of Klus Pharma
• [16] Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.
• [17] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [18] Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6.
• [19] GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.
• [20] Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75.
• [21] Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009 Aug 17;117(7):265-72.
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• [23] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)
• [24] Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart. Clin Sci (Lond). 2009 Jul 16;117(4):157-64.
• [25] A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10.
• [26] Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Current Issue vol. 111 no. 12 Celine Valant, 4614-4619.