General Information of Drug (ID: DMQA0EJ)

Drug Name
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione Drug Info
Synonyms CHEMBL204456; 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44409922
TTD Drug ID
DMQA0EJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [2]
Ro 20-1724 DM0PSCF Asthma CA23 Terminated [3]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [1]
1-dodecyl-1H-indole-2,3-dione DMK6BWV Discovery agent N.A. Investigative [4]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [1]
NSC-95397 DMX0TAM Discovery agent N.A. Investigative [5]
3-isopropyl-4-(phenylamino)naphthalene-1,2-dione DMHAJ6W Discovery agent N.A. Investigative [1]
3-isopropylnaphthalene-1,2-dione DM46ID2 Discovery agent N.A. Investigative [1]
2-(1-dodecyl-1H-indol-3-yl)acetic acid DMF2XHZ Discovery agent N.A. Investigative [4]
(E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid DMI146O Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [6]
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [2]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [7]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [7]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [7]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [8]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [1]
ADOCIAQUINONE B DMPOU86 Discovery agent N.A. Investigative [9]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [1]
4-ethoxynaphthalene-1,2-dione DMUN7KC Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [10]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [11]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [12]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [13]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [14]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [15]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [7]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [7]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [7]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
M-phase inducer phosphatase 1 (MPIP1) TTLZS4Q MPIP1_HUMAN Inhibitor [1]
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]

References

1 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
2 Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
3 Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61.
4 Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3.
5 Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4.
6 Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
9 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
10 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
11 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
12 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
13 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
14 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
15 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.