General Information of Drug (ID: DMQA1VT)

Drug Name
Autologous cell based gene therapy Drug Info
Synonyms Autologous cell based gene therapy (pulmonary hypertension)
Indication
Disease Entry ICD 11 Status REF
Pulmonary hypertension BB01 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMQA1VT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tilarginine acetate DMZBGI8 Myocardial infarction BA41-BA43 Phase 3 [3]
L-NAME DM01SR6 Hypertension BA00-BA04 Phase 2 [4]
ACCLAIM DM0FGDO Angina pectoris BA40 Phase 2 [5]
VAS-203 DMKU93J Brain injury NA07.Z Phase 2 [6]
MTR105 DMT0K4F Hypotension BA20-BA21 Phase 2 [7]
L-NIL DM6Y49D N. A. N. A. Terminated [8]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [9]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [9]
Heme DMGC287 Discovery agent N.A. Investigative [10]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Modulator [2]

References

1 A Phase I study of the transplantation of genetically marked autologous bone marrow stromal cells. Hum Gene Ther. 1998 Mar 1;9(4):591-600.
2 Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Mol Ther. 2002 Sep;6(3):422-8.
3 Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA. 2007 Apr 18;297(15):1657-66.
4 Counter-regulation by atorvastatin of gene modulations induced by L-NAME hypertension is associated with vascular protection. Vascul Pharmacol. 2009 Oct;51(4):253-61.
5 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
6 Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA). J Neurotrauma. 2014 Oct 1;31(19):1599-606.
7 Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. Cardiology. 2008;111(3):181-7.
8 Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.