Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQBP7R)

Drug Name

CAT 1004 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 2	[1]
Type-2 diabetes	5A11	Phase 1	[2]

Cross-matching ID

PubChem CID: 44626120
TTD Drug ID: DMQBP7R

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting DNA-binding factor KBF1 (p105)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
P54	DMCBEYH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
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Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[5]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[6]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[7]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[8]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[8]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[10]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[11]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[12]
XP-23829	DMELUYN	Multiple sclerosis	8A40	Phase 2	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA-binding factor KBF1 (p105)	TTUIZKC	NFKB1_HUMAN	Inhibitor	[3]
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035050)
3	Clinical pipeline report, company report or official report of Catabasis Pharmaceuticals Inc.
4	Identification of p54(nrb) and the 14-3-3 Protein HS1 as TNF-alpha-inducible genes related to cell cycle control and apoptosis in human arterial endothelial cells. J Biochem Mol Biol. 2005 Jul 31;38(4):447-56.
5	Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
6	Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene. 2001 Nov 29;20(55):8009-18.
7	Reduced astrocytic NF- B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep;124(3):411-24.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Auckland Cancer Society Research Centre report
10	Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 3;201(1):105-15.
11	DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood). 2008 Feb;233(2):180-91.
12	US patent application no. US20100278784 A1.
13	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036491)