Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQNFZE)

Drug Name

Ad5-AC6 Drug Info

Synonyms

Corgenic; AC6 gene therapy, Collateral/UCSD; Adenylyl cyclase gene therapy, Collateral/UCSD; CHF gene therapy, Collateral/UCSD; Gene therapy (CHF), Collateral/USCD; Gene therapy (adenylate cyclase), Collateral/USCD

Indication

Disease Entry	ICD 11	Status	REF
Cardiac failure	BD10-BD13	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMQNFZE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Adenylate cyclase (ADCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[3]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[4]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[3]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[5]
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[5]
		N. A.	N. A.		[6]
		N. A.	N. A.		[6]
		N. A.	N. A.		[6]
		N. A.	N. A.		[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase (ADCY)	TT2QM9D	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013170)
2	Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
5	Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.