General Information of Drug (ID: DMR9TBW)

Drug Name
4-(4-hexylphenyl)-4-oxobut-2-enoic acid Drug Info
Synonyms CHEMBL237601; SCHEMBL16227167
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
53881633
TTD Drug ID
DMR9TBW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liothyronine DM6IR3P Congenital hypothyroidism Approved [2]
Levothyroxine DMHN027 Congenital hypothyroidism Approved [3]
Dextrothyroxine Sodium DMBVEC7 High blood cholesterol level 5C80.00 Approved [4]
BCT303 DMUFY4K Hypothyroidism 5A00 Phase 2 [5]
tiratricol DMZO6CV Wound healing EL8Y Clinical trial [6]
3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one DM2JBQI Discovery agent N.A. Investigative [1]
3-(3,5-Dibromo-4-hexyloxy-phenyl)-propionic acid DMDFHCU Discovery agent N.A. Investigative [7]
3-(dimethylamino)-1-(4-hexylphenyl)propan-1-one DMJYCHG Discovery agent N.A. Investigative [1]
(3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid DM5GN46 Discovery agent N.A. Investigative [7]
1-(4-hexylphenyl)-3-morpholinopropan-1-one DMFN8T6 Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dextrothyroxine Sodium DMBVEC7 High blood cholesterol level 5C80.00 Approved [4]
BCT303 DMUFY4K Hypothyroidism 5A00 Phase 2 [5]
MB-07811 DM6JTSZ Hyperlipidaemia 5C80 Phase 2 [8]
MGL-3196 DM1HC9R Familial hypercholesterolemia 5C80.00 Phase 2 [9]
VK-2809 DMY5NUR Hypercholesterolaemia 5C80.0 Phase 2 [10]
ZYT-1 DM1XOZK Lipid metabolism disorder 5C52.Z Phase 1 [5]
Axitirome DM6L5IP Hyperlipidaemia 5C80 Phase 1 [11]
VK-0214 DM90GS3 X-linked Adrenoleukodystrophy 5C57 Phase 1 [12]
tiratricol DMZO6CV Wound healing EL8Y Clinical trial [6]
Cacodylate Ion DMK4XLD Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyroid hormone receptor alpha (THRA) TTTSEPU THA_HUMAN Inhibitor [1]
Thyroid hormone receptor beta (THRB) TTGER3L THB_HUMAN Inhibitor [1]

References

1 Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80.
2 Evaluation of thyroid hormone action in a case of generalized resistance to thyroid hormone with chronic thyroiditis: discovery of a novel heterozy... Endocr J. 2007 Dec;54(5):727-32.
3 Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6 Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34.
7 Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 589).
9 Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-beta agonist. Atherosclerosis. 2013 Oct;230(2):373-80.
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253.
12 Clinical pipeline report, company report or official report of Viking Therapeutics
13 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.