Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRHJOO)

Drug Name

SY-2101 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Acute promyelocytic leukaemia	2A60.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting F-box-like/WD repeat-containing protein TBL1X (TBL1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegavivint	DMPJ3YX	Desmoid tumour	2F7C	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
F-box-like/WD repeat-containing protein TBL1X (TBL1X)	TTAL6S1	TBL1X_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT04996030) An Open-label Phase 1 Study to Evaluate Pharmacokinetics, Safety, and Tolerability of SY-2101 in Adult Patients With Acute Promyelocytic Leukemia. U.S.National Institutes of Health.
2	Transducin beta-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma. Haematologica. 2021 Nov 1;106(11):2927-2939.
3	Tegavivint and the beta-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.