General Information of Drug (ID: DMRKTCP)

Drug Name
Retifanlimab Drug Info
Synonyms MGA012; INCMGA0012
Indication
Disease Entry ICD 11 Status REF
Neuroendocrine cancer 2B72.1 Approved [1]
Non-small-cell lung cancer 2C25.Y Phase 3 [2]
Merkel cell carcinoma 2C34 Phase 2 [3]
Metastatic colorectal cancer 2B91 Phase 2 [4]
Penile squamous cancer 2C81 Phase 1 [5]
Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Cross-matching ID
TTD Drug ID
DMRKTCP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nivolumab DMAB9QE Melanoma 2C30 Approved [8]
Tislelizumab DMGVUO5 Hodgkin lymphoma 2B30 Approved [9]
MK-3475 DMBYNW0 Melanoma 2C30 Approved [8]
Pembrolizumab DMFQEA6 Melanoma 2C30 Approved [4]
Cemiplimab DMKMJHE Cutaneous squamous cell carcinoma 2C30 Approved [10]
Sintilimab DMGWR0C Hodgkin lymphoma 2B30 Approved [11]
Dostarlimab DM78NWP Endometrial cancer 2C76 Approved [12]
Toripalimab DMSGA6Z Demodex blepharitis 1G07 Approved in China [13]
PDR001 DM53J6B Melanoma 2C30 Phase 3 [14]
BGB-A317 DM7NJYC Hepatocellular carcinoma 2C12.02 Phase 3 [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Inhibitor [7]

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761334.
2 ClinicalTrials.gov (NCT04203511) INCMGA00012 in Combination With Chemoradiation in Participants With Stage III Non-Small Cell Lung Cancer (POD1UM-301). U.S. National Institutes of Health.
3 ClinicalTrials.gov (NCT03599713) A Study of INCMGA00012 in Metastatic Merkel Cell Carcinoma (POD1UM-201). U.S. National Institutes of Health.
4 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
5 ClinicalTrials.gov (NCT04231981) Efficacy of INCMGA00012 in Penile Squamous Cell Carcinoma (ORPHEUS) (ORPHEUS). U.S. National Institutes of Health.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
9 Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
10 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
11 Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
12 Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
13 Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)