General Information of Drug (ID: DMRLV7G)

Drug Name
INCB59872 Drug Info
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1/2 [1]
Small-cell lung cancer 2C25.Y Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMRLV7G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IMG-7289 DML9AVG Acute myeloid leukaemia 2A60 Phase 2 [1]
CC-90011 DM0EDHJ Lymphoma 2A80-2A86 Phase 2 [1]
CC-90011 DM0EDHJ Lymphoma 2A80-2A86 Phase 2 [2]
Vafidemstat DM64ZGY Alzheimer disease 8A20 Phase 2 [3]
ORY-2001 DMYM0UY Alzheimer disease 8A20 Phase 2 [4]
GSK2879552 DMT3V2W Small-cell lung cancer 2C25.Y Phase 1 [5]
Seclidemstat DMCP7SD Ewing sarcoma 2B52 Phase 1 [6]
TAS-1440 DMHIA7Y Acute myeloid leukaemia 2A60 Phase 1 [7]
Tarnylcypromine derivative 2 DMEJR2F N. A. N. A. Patented [8]
Tarnylcypromine derivative 3 DMKJOMC N. A. N. A. Patented [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lysine-specific histone demethylase 1 (LSD) TTNR0UQ KDM1A_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.
3 Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis. Pharmaceutics. 2022 Jul 6;14(7):1420.
4 Clinical pipeline report, company report or official report of Oryzon Genomics Boston, MA
5 A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.
6 Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol. 2020 Sep 17;11:2196.
7 Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
8 LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.