General Information of Drug (ID: DMS6DPF)

Drug Name
ADPT01 Drug Info
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMS6DPF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nivolumab DMAB9QE Melanoma 2C30 Approved [2]
Tislelizumab DMGVUO5 Hodgkin lymphoma 2B30 Approved [3]
MK-3475 DMBYNW0 Melanoma 2C30 Approved [2]
Pembrolizumab DMFQEA6 Melanoma 2C30 Approved [4]
Cemiplimab DMKMJHE Cutaneous squamous cell carcinoma 2C30 Approved [5]
Retifanlimab DMRKTCP Neuroendocrine cancer 2B72.1 Approved [6]
Sintilimab DMGWR0C Hodgkin lymphoma 2B30 Approved [7]
Dostarlimab DM78NWP Endometrial cancer 2C76 Approved [8]
Toripalimab DMSGA6Z Demodex blepharitis 1G07 Approved in China [9]
PDR001 DM53J6B Melanoma 2C30 Phase 3 [10]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Relatlimab DM28AZV Melanoma 2C30 Approved [11]
Anti-LAG3 DMJO402 Gastric adenocarcinoma 2B72 Phase 2 [6]
BMS-986016 DMDCHM7 Hematologic tumour 2B33.Y Phase 1/2 [12]
IMP-321 DM18ZLW Allergy 4A80-4A85 Phase 1/2 [13]
Favezelimab DMYAIE2 Non-hodgkin lymphoma 2B33.5 Phase 1/2 [14]
XmAb22841 DMQB3HD Solid tumour/cancer 2A00-2F9Z Phase 1 [15]
FS118 DM0QH9K Advanced cancer 2A00-2F9Z Phase 1 [4]
RG6139 DMJFM3O Solid tumour/cancer 2A00-2F9Z Phase 1 [16]
IMP-701 DMXSMF9 Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
GSK2831781 DMC47M9 Autoimmune disease 4A40-4A45 Phase 1 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lymphocyte activation gene 3 protein (LAG3) TTNVXAW LAG3_HUMAN Inhibitor [1]
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of Novartis.
2 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
3 Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
4 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
5 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
8 Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
9 Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761234
12 Nivolumab in NSCLC: latest evidence and clinical potential. Ther Adv Med Oncol. 2015 March; 7(2): 85-96.
13 A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol. 2007 Sep 15;179(6):4202-11.
14 A first-in-human study of the anti-LAG-3 antibody favezelimab plus pembrolizumab in previously treated, advanced microsatellite stable colorectal cancer. ESMO Open. 2022 Dec;7(6):100639.
15 Clinical pipeline report, company report or official report of Xencor.
16 Clinical pipeline report, company report or official report of Genentech.
17 IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007 Mar 29;5:5.